The Swire Shipping Fijian Drua have to win their next three games in order to qualify for the Shop N Save Super Rugby Pacific quarter finals for the second time in just their third season.
That starts with the Reds this Saturday, who are standing in their way hoping to make it into the top four for the advantage of home ground in the playoffs.
The Reds are currently fifth on the table with 31 points while the Drua are currently eighth with 17.
Waqa Nalaga will get his first ever start at inside centre with Iosefo Masi in the midfield.
Prop Jone Koroiduadua returns from suspension with Etonia Waqa and Elia Canakaivata the notable changes in the forwards.
Simione Kuruvoli starts ahead of Peni Matawalu and Epeli Momo returns to the left wing in place of Taniela Rakuro who will come off the bench.
The Byrne coached side have only won one out of their three games against the Reds thumping them 41-17 last year.
The Drua host the Reds at 2.05pm Saturday at the HFC Bank Stadium.
In other games, the Hurricanes will take on Moana Pasifika at 7.05pm tomorrow, the Rebels will host the Chiefs at 9.35pm tomorrow, the Brumbies will play the Crusaders at 4.35pm Saturday, the Blues will battle the Highlanders at 7.05pm Saturday and the Force host the Waratahs at 9.35pm Saturday.
